Aunt May once caught Spider-Man sneaking into her home and took him out with a flower vase. This is a big deal. Roughly 90% of Spider-Man's enemies never even land a hit, because he has the 25 best superpowers specifically for fucking you up. Spider-Man villains scream things like "All sculpted bushes are now under the command of The Living Topiary!" before finding out their amazing ability isn't as useful as kicking hard and dodging any attack from any direction. Half the time, Spidey has to carefully pull his punches so as not to splatter his enemies' fragile organs against the inside of their skeletons. But look what happens when he crosses paths with May Parker:
The comic exhaustively explains how Spider-Man is unable to dodge the attack because his dear Aunt May doesn't trigger his Spider-Sense, which is a bizarre weakness that will come up later. The point is, Peter has faced literally tens of thousands of foes outfitted with weaponry and abilities from across time and space, and maybe 20 of them have kicked his ass as hard as Aunt May does with a vase.